At a glance
Type
Nonapeptide (sleep peptide)
Molecular weight
≈848.8 g/mol
Studied for
SleepStress / cortisolDelta sleep
DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nine-amino-acid peptide first isolated from the brain in 1977. As its name suggests, it is studied mainly for sleep — specifically slow-wave (delta) sleep — and for its effects on the stress axis.
How DSIP works
DSIP is a neuropeptide proposed to help regulate deep, slow-wave sleep and to dampen the body’s stress response, including the HPA (hypothalamic-pituitary-adrenal) axis and cortisol release. Experimental work shows it can reduce CRF-driven corticosterone secretion, apparently acting at the pituitary. Its exact receptor targets and mechanism, however, remain incompletely understood.
What the research shows
- Original isolation (Schoenenberger & Monnier, 1977). The first characterisation of DSIP as a delta-sleep-inducing factor from rabbit brain.
- Stress axis (Graf et al., 1985). DSIP attenuated CRF-driven corticosterone, suggesting a pituitary-level effect on the stress response.
- Insomnia study (Bes et al., 1992). A double-blind study reported improved sleep efficiency and shorter sleep latency versus placebo.
Candour: DSIP’s mechanism is poorly understood, and the human evidence is mixed and limited — mostly small, older clinical studies plus animal work. Use belongs under a physician’s guidance.
Molecular specification
| Type | Nonapeptide (delta sleep-inducing peptide) |
| Sequence | Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu |
| Molecular formula | C35H48N10O15 |
| Molecular weight | ≈848.8 g/mol |
| CAS number | 62568-57-4 |
Quality and sourcing
Every batch of Azzurri Wellness DSIP is compounded through a Registered 503B outsourcing facility under GMP-compliant processes, HPLC-tested for purity and potency, and third-party lab verified. Shipped cold-pack when needed to protect stability.
References
- Schoenenberger GA, Monnier M. Characterization of a delta-EEG(-sleep)-inducing peptide. Proc Natl Acad Sci USA. 1977;74(3):1282–1286. PubMed
- Graf MV, et al. Delta-sleep-inducing peptide reduces CRF-induced corticosterone release. Neuroendocrinology. 1985;41(4):353–356. PubMed
- Bes F, et al. Effects of delta sleep-inducing peptide on sleep of chronic insomniac patients: a double-blind study. Neuropsychobiology. 1992;26(4):193–197. PubMed
Compiled by the Azzurri Wellness Research Team and checked against the cited literature. Educational only — not medical advice.
